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Antituberculosis Drugs
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This volume represents the first comprehensive review of the preclinical evaluation of all 14 antituberculosis drugs which have come into clinical use from the beginnings of antituberculosis chemotherapy to the present. The following topics are dealt with exhaustively for each drug: chemical properties; experimental activity in vitro in cells, and in animals; type and mechanism of action; experimental pharmacology and toxicology; and pharmacokinetics in animals and man. The experimental aspects of the combined use of antituberculotics, which is essential for the success of treatment in human tuberculosis, are described in full. A special chapter is devoted to the use of antituberculotics and other antimicrobial agents in the experimental and clinical chemotherapy of mycobacterioses due to socalled atypical mycobacteria.
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