Biomacromolecular Crystallization Across Experimentation and Modeling

This book comprehensively reviews biomacromolecular crystallization across experimentation and modelling and, together with its companion volume "Fundamentals of Biomacromolecular Crystallization: Insights into Thermodynamics and Kinetics", offers a quantitative-oriented perspective, from thermodynamics and kinetics fundamentals to scalable continuous processes. Divided into 3 sections, the book begins with an overview of reported crystallizers for biomolecular crystallization experimentation, followed by a discussion about the use of process analytical technology (PAT) for the development of biomolecular crystallization. In the 3rd part of the book, readers will learn about the modelling of biomolecular crystallization processes. Expert contributors cover topics such as biomolecular crystallization in microfluidic devices, continuous crystallization platforms, in-situ online spectroscopy and light scattering techniques, and mathematical modelling applied for biomolecular crystallization. Particular attention is given to the recent developments in biomolecular crystallization modelling, including advancements in AI and ML.

This book serves as a valuable resource for designing and performing successful biomolecular crystallization experiments. Given its breadth, it appeals to scholars and researchers from both academia and industry, working in the field of biomolecular crystallization across several study areas, such as biochemistry, engineering, and biotechnology, among others.