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Membrane Defenses Against Attack by Complement and Perforins
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In this volume a comprehensive review of membrane proteins§that regulate complement and perforin-mediated cytolysis is§presented. A detailed analysisis provided of the§biochemical, molecular, and functional features of these§proteins; the glycosyl phosphatidylinositol linked§proteins are covered, with emphasis placed on the functional§importance of this type of membrane anchor. Further chapters§include reviews of the effects of complement activation on§cells that are metabolically active, and of the regulation§of cell killing by cytotoxic lymphocytes, considering the§similarities and disparities between the complement and§perforin systems. The therapeutic use of recombinant CR1§for immune-mediated pathophysiological processes is§discussed in a separate section.
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