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Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems
Engleski
249 b
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The book§presents a new, powerful model of neuronal networks, consisting of a§three-dimensional neuronal culture in which 3D neuronal networks are coupled to§micro-electrode-arrays (MEAs). It discusses the main advantages of the§three-dimensional system compared to its two-dimensional counterpart, and shows§that the network dynamics, recorded during both spontaneous and stimulated§activity, differs between the two models, with the 3D system being better able§to emulate the in vivo behaviour of neural networks. The book offers an§extensive analysis of the system, from the theoretical background, to its§design and applications in neuro-pharmacological studies. Moreover, it§includes a concise yet comprehensive introduction to both 2D and 3D neuronal§networks coupled to MEAs, and discusses the advantages, limitations and§challenges of their applications as cellular and tissue-like in vitro experimental model systems.§§
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