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This textbook illustrates and explains the power of process simulation for the analysis of chemical processes and for the conceptual design of unit operations. In recent years, the evolution of informatics tools has opened a broad spectrum of possibilities in the use of applications for process integration, dynamic analysis, costs evaluation and conceptual design of separation and reaction operations. This book discusses the importance of process simulation for process safety, green engineering, economic profitability, and other areas. This textbook will have worked examples and proposed exercises at the end of each chapter. The solutions manual for the exercises will be available to instructors. The authors, having thoroughly tested this material in the classroom, first introduce the fundamentals of process simulation in steady state, and then discuss process simulation in the context of various important principles of chemical engineering. Practical examples abound and make this book relevant also for industrial practitioners. The book closes with optimization, dynamic analysis of processes, and case studies.