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This paper examines modern methods of analytical quality control and quantitative determination of pharmaceuticals. Particular attention is paid to the use of physicochemical and instrumental analytical methods that ensure the accuracy, reliability, and reproducibility of results. The effectiveness of methods for determining the authenticity, purity, and quantitative content of active ingredients in pharmaceuticals was evaluated. The data obtained confirm the importance of analytical control at all stages of pharmaceutical production and distribution to ensure their quality, safety, and efficacy.