Kontakt
Kako kupovati
Dostava
Savjetnik za kupnju
Razoxane and Dexrazoxane - Two Multifunctional Agents
Experimental and Clinical Results
Engleski
373 b
Do 30 dana za povrat
Kupci su kupili i
/
Meki uvez
32.16
€
/
Meki uvez
43.79
€
Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of patho-logical blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. §They protect normal tissues against toxic chemicals, e.g. the myocardium against anthra-cyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthra-cyclines. Dexrazoxane is the only drug approved by the FDA/UMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthra-cyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topo-isomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc.§The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer s disease could be stabilized by one or both these drugs.
Informacije o knjizi
Engleski
Kategorija
Poklonite ovu knjigu još danas
To je jednostavno
1 Dodajte knjigu u košaricu i odaberite isporuku kao poklon 2 Zauzvrat ćemo vam poslati kupon 3 Knjiga dolazi na adresu poklonoprimcaMoglo bi vas zanimati i
/
Meki uvez
9.30
€
/
Meki uvez
43.59
€
