The Physics of Protein Structure and Dynamics

The Physics of Protein Structure and Dynamics: When and Why Proteins Fold or Don’t Fold addresses an overlooked issue in current books in the field - folding, misfolding, and intrinsically disordered proteins (vide infra). The book looks at protein folding and intrinsically disordered proteins, which must be seen as heavily interrelated topics that need to be viewed together. The book also looks at the physics of protein/peptide aggregation. Since intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow), IDPs and protein self-assembly must be considered together. Moreover, protein aggregation cannot be separated from protein folding since it is frequently the product of misfolding. The proposed book will demonstrate the relationships between protein folding, non-folding and aggregation and emphasize the underlying physics. Provides an in-depth overview of the physical concepts that govern different aspects of protein folding, disorder and self-assembly. By emphasizing the relationship between these issues, the approach adds a holistic character to the bookFor instructors, the book offers a unique source for teaching of current protein physics issuesConstruction of the book (multiple references to primary literature with DOI links, literature-based problem sets and topics for discussion) will facilitate a learning process suitable for research-oriented students