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The Synthesis of an Internal Standard for Bicalutamide

Name: The Synthesis of an Internal Standard for Bicalutamide
Brand: LAP Lambert Academic Publishing
SKU: 15201248
Price: 49.41 EUR
Availability: InStock
Author: Maryam Amra Jordaan
ISBN: 9783659954313

Maryam Amra Jordaan

Jan van der Westhuizen

Jezik

Engleski

Knjiga Meki uvez

Libristo kod: 15201248

Nakladnici LAP Lambert Academic Publishing, studeni 2015

(R,S)-Bicalutamide [N-(4-cyano-3-trifluoromethylphenyl)- -methyl- -hydroxy-beta-(4- fluorophenylsulf... Cijeli opis

Libristo kod: 15201248

121 b

49.41 €

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(R,S)-Bicalutamide [N-(4-cyano-3-trifluoromethylphenyl)- -methyl- -hydroxy-beta-(4- fluorophenylsulfonyl)propanamide], sold as Casodex®, is the leading antiandrogen currently used to treat prostate cancer. It binds to androgen receptors and blocks cancer growth. This work aims to develop internal standards for the bio-analytical component of clinical trials that are required to detect bicalutamide and derivatives. An internal standard is added to the body fluid sample (mostly blood) at the beginning of the sample work up at about the same concentration of the analyte to be quantified. An ideal internal standard has a similar extraction recovery and a similar retention time in HPLC. For quantification with mass spectrometry it should have a difference of at least 3 mass units from the analyte and a similar ionization response. The internal standard is used to calibrate the total ion current of the metabolite.