Kontakt
Kako kupovati
Dostava
Savjetnik za kupnju
VIP Protects Th2 Cells by Downregulating Granzyme B Expression
Engleski
138 b
Do 30 dana za povrat
Kupci su kupili i
/
Meki uvez
17.45
€
/
Meki uvez
53.28
€
/
Meki uvez
25.12
€
Following antigenic stimulation, CD4+ T cells§differentiate into Th1 and Th2 effectors, with§different cytokine profiles and different§physiological functions. However, regardless of the§initial Th1/Th2 balance, the final immune response§depends to a large degree on the regulation of Th1 or§Th2 survival under specific conditions. §The major purpose of this thesis was to identify and§characterize the molecular mechanisms for the§protective effect of VIP on Th2 effectors in an in§vitro system. Our experiments revealed a surprising§new mechanism involved in Th1/Th2 AICD, i.e. the§induction of enzymatically active granzyme B (GrB)§upon T cell receptor restimulation. In wild-type Th1§and Th2 cells, apoptosis is mediated through both Fas§signaling and GrB induction. In lpr (Fas mutant) Th1§and Th2 effectors T cell receptor restimulation§results in apoptosis mediated solely by GrB,§suggesting that GrB induction is independent of Fas§signaling. VIP induces the survival of wild-type Th2§effectors by preventing the induction of GrB and the§upregulation of FasL expression in Th2, but not Th1§cells.
Informacije o knjizi
Engleski
Kategorija
Poklonite ovu knjigu još danas
To je jednostavno
1 Dodajte knjigu u košaricu i odaberite isporuku kao poklon 2 Zauzvrat ćemo vam poslati kupon 3 Knjiga dolazi na adresu poklonoprimcaMoglo bi vas zanimati i
/
Meki uvez
80.93
€
/
Meki uvez
22.90
€
Dobar dan! Ja sam Libroamiko, vaš književni savjetnik.
Kako vam mogu pomoći?