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New Algorithms for Single Particle Cryo Electron Microscopic Image Processing

Jezik EngleskiEngleski
Knjiga Meki uvez
Knjiga New Algorithms for Single Particle Cryo Electron Microscopic Image Processing Jan-Martin Kirves
Libristo kod: 12828738
Nakladnici Cuvillier Verlag, siječanj 2015
In this thesis four approaches to increase the quality and assure the validity of three-dimensional... Cijeli opis
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In this thesis four approaches to increase the quality and assure the validity of three-dimensional (3D) models generated within the single particle cryo-electron microscopy (CryoEM) workflow are introduced. ProteoPlex is a high-throughput technique and software tool for the evaluation of the most stabilizing biochemical conditions of macromolecular complexes. The validation technique 3D correlation of tilted pairs (3DCTP) can be applied alongside the single particle refinement cycle to detect model bias utilizing tilted pair images. A new analysis method identifies the presence of overfitting in high resolution CryoEM 3D structures. Finally, a set of criteria covering different model quality aspects of the generated 3D structure is introduced.

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Informacije o knjizi

Puni naziv New Algorithms for Single Particle Cryo Electron Microscopic Image Processing
Autor Jan-Martin Kirves
Jezik Engleski
Uvez Knjiga - Meki uvez
Datum izdanja 2015
Broj stranica 174
EAN 9783954049073
ISBN 3954049074
Libristo kod 12828738
Nakladnici Cuvillier Verlag
Težina 234
Dimenzije 148 x 210 x 9

Kategorija

Mathematics & Science > Biology, life sciences > Microbiology (non-medical)
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